Endocrine Abstracts

Introduction: Ketosis-prone diabetes or Flatbush diabetes has been recognized as a clinical entity since 1984. Is characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic syntoms (usually poyiuria, polydipsia and weight loss are present for less than 4 weeks). Unlike the insulin dependence seen in type 1 diabetes, after a few weeks (usually 2 to 12 weeks), insulin requeriments decrease, and approximately 70% of patients achieve remissio...

Introduction: NutriScore is a tool designed with the aim of simplifying the information of the nutritional composition obtained from the labelling. It classifies foods into five colors ranging from green (healthier) to red (less healthy). These colors are associated with five letters (A/B/C/D/E).Objective: To examine the nutritional value of foods sold in vending machines of the public hospitals in Community of Madrid (Spain), by calculating the nutrisco...

Aim: Evaluation of hypocortisolism and replacement treatment after transsphenoidal surgery pituitary adenomas and subsequent follow-up in Endocrinology offices.Material and methodWe conducted a retrospective intra-subject study of patients with pituitary adenomas who were undergone surgery. Clinical and analytical data were evaluated at baseline and after surgery between 2012–2018.Results: 30 patients (...

Objectives: MODY diabetes is the most common form of monogenic diabetes, encompassing a heterogeneous group of disorders whose primary defect results from mutations in one of at least seven genes recognized, associated with a primary defect in insulin secretion. It has early onset and autosomal dominant inheritance.Our objective was to evaluate the results of monogenic diabetes clinic of the Endocrinology and Nutrition Department during 2008–2012.</...

Childhood obesity has become a major health problem, which is coupled to different adverse outcomes and diseases. The escalating prevalence of child obesity parallels that of alterations in pubertal timing, also linked to higher disease burden later on life. Yet, the mechanisms underlying for this association remain unfolded. Ceramides, ubiquitous signaling molecules involved in numerous biological processes, have emerged as mediators of metabolic disorders and transmitters fo...

Pituitary adenomas (PA), as well as pheochromocytomas and paragangliomas, are neuroendocrine tumors that arise from cells derived from the pituitary, adrenal and extra-adrenal nervous system, respectively. Recent studies have identified a growing series of susceptibility genes for these pathologies. Some genes may be associated with the development of both types of pathologies, as it is the case for succinate dehydrogenase complex genes, while, PAs have not been reported to da...

Introduction: The Carney-Stratakis syndrome (CSS) is an inherited condition caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C or D that predispose to gastric stromal tumors (GIST) and multicentric paragangliomas (PGL). SDH acts as a tumor suppressor gene, and enzyme activity reduction is known to be oncogenic. Since 2002 there has been some scarce reports. We present a new case of CSS associated with a germline unknown significance mutation in exon 4 ...

IntroductionThe term collision tumor refers to the coexistence of two histologically distinct malignant neoplasms. The two malignancies can originate from the same organ or occur as metastases from other regions. This type of tumors involving the thyroid gland are especially rare. Reported cases are usually involving papillary thyroid carcinomas in coexistence with other types of tumors like medullary carcinoma, follicular carcinoma or metastasic disease...

IntroductionMalignant insulinoma is a rare pancreatic neuroendocrine tumor that accounts for only 10% of all cases of insulinoma. The clinical picture is characterized by the presence of severe hyperinsulinemic hypoglycaemic syndrome in a patient with pancreatic tumor with locoregional and/or distant metastases. Therapeutic management is challenging due to the need to control both hypoglycemic syndrome and tumor growth. Curative surgery is rarely applica...

Introduction and Objective: Pheochromocytomas are usually monocomponent tumors, but very rarely there are also composite pheochromocytomas, with another medullary component (benign or malignant) derived from the neural crest present. Even more rarely there are mixed corticomedullary tumors, with pheochromocytoma plus a cortical adrenal tumor, eventually causing primary aldosteronism or hypercortisolim. Our objective in this communication is to illustrate an infrequent variety ...